Type of Document Master's Thesis Author Ross, Amy Patricia Author's Email Address aross17@student.gsu.edu URN etd-04142008-092756 Title Effects of a High Fructose Diet on Physiology and Cognition in Male Sprague-Dawley Rats Degree Master of Arts Department Psychology Advisory Committee
Advisor Name Title Marise B. Parent, Ph.D. Committee Chair Kim L. Huhman, Ph.D. Committee Member Timothy J. Bartness, Ph.D. Committee Member Keywords
- Fructose
- Morris water maze
- Diet
- Memory
- Hippocampus
- Triacylglycerides
- Free fatty acids
Date of Defense 2008-03-11 Availability unrestricted Abstract Fructose consumption has increased exponentially during the past four decades. The physiological effects of a high fructose diet include obesity and insulin resistance. In animal models, the effects of a high fructose diet on fat distribution are inconclusive in that some studies find increases in body mass and lipids while others find no effect. Recent findings indicate that a high fructose diet causes hippocampal insulin resistance in hamsters, raising the possibility that the diet causes impairments in cognition. The following experiments tested the hypotheses that a high fructose diet alters fat distribution rather than total body mass and impairs hippocampal-dependent memory. Results indicated that the high fructose diet did not affect fat distribution, but did increase plasma triacylglycerides. Interestingly, the diet also impaired spatial reference memory in the Morris water maze, and this effect was correlated with plasma triacylglycerides. These results indicate that a high fructose diet impairs brain function.Files
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