Type of Document Master's Thesis Author Akcin, Haci Mustafa Author's Email Address hmakcin@gmail.com URN etd-04182008-095207 Title DIRECT ADJUSTMENT METHOD ON AALEN’S ADDITIVE HAZARDS MODEL FOR COMPETING RISKS DATA Degree Master of Science Department Mathematics and Statistics Advisory Committee
Advisor Name Title Dr.Xu Zhang Committee Chair Dr.Jiawei Liu Committee Member Dr.Yichuan Zhao Committee Member Dr.Yu-Sheng Hsu Committee Member Keywords
- Survival function
- Cumulative incidence function
- Competing risks
- Survival analysis
- Aalen’s additive hazards model
- Direct adjustment method
Date of Defense 2008-04-10 Availability unrestricted Abstract ABSTRACTAalen’s additive hazards model has gained increasing attention in recently years because it model all covariate effects as time-varying. In this thesis, our goal is to explore the application of Aalen’s model in assessing treatment effect at a given time point with varying covariate effects. First, based on Aalen’s model, we utilize the direct adjustment method to obtain the adjusted survival of a treatment and comparing two direct adjusted survivals, with univariate survival data. Second, we focus on application of Aalen’s model in the setting of competing risks data, to assess treatment effect on a particular type of failure. The direct adjusted cumulative incidence curve is introduced. We further construct the confidence interval of the difference between two direct adjusted cumulative incidences, to compare two treatments on one risk.
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