Type of Document Master's Thesis Author Barnes, Samuel Author's Email Address sbarnes2@student.gsu.edu URN etd-05012008-164917 Title SYNTHESIS OF 2,4-DISUBSTITUTED PYRIMIDINES OF POSSIBLE BIOLOGICAL INTEREST Degree Master of Science Department Chemistry Advisory Committee
Advisor Name Title Dr. Lucjan Strekowski Committee Chair Dr. A.L. Baumstark Committee Member Dr. Jerry Smith Committee Member Keywords
- 2-chloropyrimidine
- lithium
- lithiated
- heterocycle
- heterocyclic
- serotonin
- pyrimidine
- synthetic
- synthesis
- Organic
- organic chemistry
Date of Defense 2008-04-21 Availability unrestricted Abstract The synthesis of 2,4-disubstituted pyrimidine derivatives is described. The synthetic route involved the addition reaction of lithiated intermediates, mostly heterocycles, to position 4 of 2-chloropyrimidine to give a dihydropyrimidine intermediate which was oxidized back to a pyrimidine. This was followed by nucleophilic aromatic substitution with various amines of the chlorine in the position 2. A number of compounds were prepared which showed binding towards various serotonin receptors in preliminary biological evaluation.Files
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