Type of Document Master's Thesis Author Ma, Baofu Author's Email Address bma1@student.gsu.edu URN etd-06192005-183001 Title Analyzing The Combination of Polymorphisms Associating With Antidepressant Response By Exact Conditional Test Degree Master of Science Department Mathematics and Statistics Advisory Committee
Advisor Name Title Susmita Datta Committee Chair Gengsheng Qin Committee Member Yichuan Zhao Committee Member Keywords
- Marginal independence
- Conditional independence
- Enumerating
- High-dimensional table
- Exact test
- Contingency
- Antidepressant
Date of Defense 2005-05-10 Availability unrestricted Abstract Genetic factors have been shown to be involved in etiology of a poor response to the antidepressant treatment with sufficient dosage and duration. Our goal was to identify the role of polymorphisms in the poor response to the treatment. To this end, 5 functional polymorphisms in 109 patients diagnosed with unipolar, major depressive disorder are analyzed. Due to the small sample size, exact conditional tests are utilized to analyze the contingency table. The data analysis involves: (1) Exact test for conditional independence in a high dimensional contingency table; (2) Marginal independence test; (3) Exact test for three-way interactions. The efficiency of program always limits the application of exact test. The appropriate methods for enumerating exact tables are the key to improve the efficiency of programs. The algorithm of enumerating the exact tables is also introduced.Files
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