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Title page for ETD etd-07122007-100300


Type of Document Master's Thesis
Author Oliver, Jennifer Betts
Author's Email Address jenniferol@pcom.edu
URN etd-07122007-100300
Title The Prevalence of Nelson Bay Virus in Humans and Bats and Its Significance within the Framework of Conservation Medicine
Degree MPH
Department Public Health
Advisory Committee
Advisor Name Title
Karen Gieseker Committee Chair
Andy Comer Committee Member
John Steward Committee Member
Keywords
  • Megachiropterans
  • conservation medicine
  • emerging infectious disease
  • nipah virus
  • orthoreovirus
  • Nelson Bay virus
  • bats
  • bangladesh
Date of Defense 2007-07-11
Availability unrestricted
Abstract
Public health professionals strive to understand how viruses are distributed in the environment, the factors that facilitate viral transmission, and the diversity of viral agents capable of infecting humans to characterize disease burdens and design effective disease intervention strategies. The public health discipline of conservation medicine supports this endeavor by encouraging researchers to identify previously unknown etiologic agents in wildlife and analyze the ecologic of basis of disease. Within this framework, this research reports the first examination of the prevalence in Southeast Asia of the orthoreovirus Nelson Bay virus in humans and in the Pteropus bat reservoir of the virus. Contact with Pteropus species bats places humans at risk for Nipah virus transmission, an important emerging infectious disease. This research furthermore explores the environmental determinants of Nelson Bay and Nipah viral prevalence in Pteropus bats and reports the characterization of two novel orthoreoviruses isolated from bat tissues collected in Bangladesh.
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