Type of Document Master's Thesis Author zhang, xinjian URN etd-07262007-123251 Title HIV/AIDS RELATIVE SURVIVAL AND MEAN RESIDUAL LIFE ANALYSIS Degree Master of Science Department Mathematics and Statistics Advisory Committee
Advisor Name Title Gengsheng (Jeff) Qin Committee Chair Ruiguang (Rick) Song Committee Co-Chair Xu Zhang Committee Member Yu-Sheng Hsu Committee Member Keywords
- HIV
- AIDS
- Survival
- Mean residual life (MRL)
Date of Defense 2007-06-19 Availability unrestricted Abstract HIV/AIDS RELATIVE SURVIVAL AND MEAN RESIDUALLIFE ANALYSIS
BY
XINJIAN ZHANG
Under the Direction of Gengsheng (Jeff)
Qin and Ruiguang (Rick) Song
ABSTRACT
Generalized linear models with Poisson error were applied to investigate HIV/AIDS relative survival. Relative excess risk for death within 3 years after HIV/AIDS diagnosis was significantly higher for non-Hispanic blacks,
American Indians and Hispanics compared with Whites. Excess hazard for death was also higher in men injection drug users compared with men who have sex with men (MSM). The relative excess hazard of old HIV/AIDS patients is significantly higher compared with younger patients. When CD4 increased, the relative excess hazard decreased; while with the increase of HIV viral load, the
relative excess hazard decreased. This is the first study to use national wide
data to examine the significance of HIV viral load as a determinant risk
factor of disease progression after HIV infection; The mean residual lie needs to
be further analyzed.
INDEX WORDS: Human Immunodeficiency Virus (HIV), Acquired Immunodeficiency Syndrome (AIDS), Survival, Mean residual life (MRL).
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