Type of Document Master's Thesis Author Patel, Nehal Jitendralal Author's Email Address npatel51@student.gsu.edu URN etd-07262007-154647 Title COMPARSION OF ANTIBIOTIC SENSITIVITY PROFILES, MOLECULAR TYPING PATTERNS, AND ATTRIBUTION OF SALMONELLA ENTERICA SEROTYPE NEWPORT IN THE U.S., 2003-2006 Degree MPH Department Public Health Advisory Committee
Advisor Name Title Dr. Karen Gieseker Committee Chair Dr. Michael Eriksen Committee Member Dr. Peter Gerner-Smidt Committee Member Kelley Hise Committee Member Keywords
- PFGE
- Salmonella Newport
- Attribution analysis
- antimicrobial sensitivity testing
Date of Defense 2007-07-16 Availability unrestricted Abstract Salmonella causes gastrointestinal illness in humans. The purpose of the study was to determine the relative contribution of different food commodities to sporadic cases of salmonellosis (attribution analysis) caused by Salmonella Newport (SN) using Pulsed-Field Gel Electrophoresis (PFGE) patterns and antimicrobial sensitivity (AST) data submitted by public health laboratories and regulatory agencies from 2003 to 2006. The genetic relationship between isolates from non-human (348) and human (10,848) sources was studied by two unique clustering methods: UPGMA and Ward. Results show poultry was the highest contributor of human SN infections, followed by tomatoes and beef. Beef was the largest contributing food commodity of multi-drug resistant (MDR)-AmpC infection patterns. Results from this pilot study show that PFGE and AST can be useful tools in performing attribution analysis at the national level and that SN MDR-AmpC patterns are decreasing and seem to be restricted to isolates from animal sources.Files
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