Type of Document Master's Thesis Author Gunderson, Kristin M Author's Email Address kgunder@emory.edu URN etd-07272007-135518 Title The Etiology of Multiple Sclerosis and Correlation of the Distribution of the Disease with Migration and Settlement History of Northern Europeans Degree MPH Department Public Health Advisory Committee
Advisor Name Title Ike S. Okosun, Ph.D., M.S. Committee Chair John Steward, M.P.H. Committee Member Ruoxiang Wang, M.D., Ph.D. Committee Member Keywords
- incidence
- prevalence
- epidemiology
- multiple sclerosis
Date of Defense 2007-07-16 Availability unrestricted Abstract The geographic disparity of multiple sclerosis has been noted in the literature for well over a century. The frequency of the disease varies significantly both within countries and in different parts of the world. The goal of this project is to give new insight regarding the etiology of multiple sclerosis. Several theories regarding the etiology of the disease have been reviewed, including a geographic theory, a nutritional theory, and a genetic theory. Although the geographic and nutritional theories have been thoroughly investigated by researchers, neither of them provides a conclusive explanation for the etiology of the disease, and there are discrepancies with respect to both theories. The purpose of this study is to reveal the discrepancies in the epigenetic theories regarding the etiology of multiple sclerosis and to demonstrate the correlation of multiple sclerosis prevalence and the migration and settlement history of Northern Europeans, thus conferring the passage of a genetic susceptibility to the disease.Files
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