Type of Document Master's Thesis Author Rogers, Joy Michelle URN etd-11142006-155616 Title CHANGEPOINT ANALYSIS OF HIV MARKER RESPONSES Degree Master of Science Department Mathematics and Statistics Advisory Committee
Advisor Name Title Pulak Ghosh Committee Chair Jun Han Committee Member Xu Zhang Committee Member Yu-Sheng Hsu Committee Member Keywords
- CD4 count
- CD8 count
- Viral RNA load
- DIC
- Changepoint analysis
Date of Defense 2006-11-10 Availability unrestricted Abstract We will propose a random changepoint model for the analysis of longitudinal CD4 and CD8 T-cell counts, as well as viral RNA loads, for HIV infected subjects following highly active antiretroviral treatment. The data was taken from two studies, one of the Aids Clinical Group Trial 398 and one performed by the Terry Beirn Community Programs for Clinical Research on AIDS. Models were created with the changepoint following both exponential and truncated normal distributions. The estimation of the changepoints was performed in a Bayesian analysis, with implementation in the WinBUGS software using Markov Chain Monte Carlo methods. For model selection, we used the deviance information criterion (DIC), a two term measure of model adequacy and complexity. DIC indicates that the data support a random changepoint model with the changepoint following an exponential distribution. Visual analyses of the posterior densities of the parameters also support these conclusions.Files
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