Type of Document Master's Thesis Author Gerhardt, Dawson Author's Email Address dgerhardt2@gsu.edu URN etd-11302006-232137 Title The role of S7, a subunit of the 19S proteasome, in the transcriptional regulation of MHC II. Degree Master of Science Department Biology Advisory Committee
Advisor Name Title Susanna Greer Committee Chair Delon Barfus Committee Member Yuan Liu Committee Member Keywords
- MHC II
- Stranscription
- S7
- adaptive immunity
- proteasome
Date of Defense 2006-07-26 Availability unrestricted Abstract Induction of an adaptive, or antigen specific, immune response is critical for eliminating most infections. Pathogen clearance is accomplished primarily, by the actions of CD4+ T cells through their ability to recognize foreign antigens presented at the cell surface by major histocompatibility class II (MHC II) molecules. Consequently, the capacity to regulate expression of MHC molecules is essential to control the adaptive immune response. MHC molecules are regulated at the level of transcription by a master regulator, the class II transcriptional activator, CIITA. Thus, the expression of MHC II is directly related to proper CIITA activity. This thesis focuses on the novel role of S7, an ATPase subunit of the 19S proteasome, in the transcriptional regulation of CIITA and MHC II molecules.Files
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