Type of Document Master's Thesis Author Cisse, Ramata Sissoko Author's Email Address Rahsis@hotmail.com URN etd-12012006-233932 Title Septal Infusions of the H-Channel Blocker ZD7288 Impair Spontaneous Alternation but not Inhibitory Avoidance Degree Master of Arts Department Biology Advisory Committee
Advisor Name Title Marise B Parent Committee Chair Keywords
- ZD7288.
- Learning
- memory
- GABA
- SA
- CMIA
Date of Defense 2006-10-04 Availability unrestricted Abstract It is well established that the septo-hippocampal system is involved in memory. The medial septum is connected to the hippocampus via the fimbria fornix, which consists mostly of acetylcholine and ã-aminobutyric acid (GABA) projection neurons. The contributions of the cholinergic projection to memory have been studied extensively; whereas, the role of the GABAergic projection is not well characterized. The present experiment tested whether septal infusions of the selective H-channel blocker ZD7288 would impair spontaneous alternation (SA) and continuous multiple inhibitory avoidance (CMIA). Fifteen minutes prior to assessing SA or CMIA, different groups of male Sprague-Dawley rats were given septal infusions of saline or ZD7288 (0.2, 0.6 or 1.5 nmol / 0.5ìl). Our results indicate that septal infusions of ZD7288 impaired SA in a dose-dependent manner; the same infusions did not affect CMIA. This is the first demonstration that H-channels on septo-hippocampal GABAergic projection neurons are involved in memory.Files
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